藥靶模型
Drug Target Model

背景
機體具有完善精密的免疫調節和免疫監視功能,當腫瘤細胞侵襲時(shí),免疫系統可以識別腫瘤細胞表面的腫瘤特異性抗原 (Tumour-associated antigens,TAAs),激活特異性體液免疫應答和細胞免疫應答,清除入侵的腫瘤細胞;同時(shí),腫瘤細胞也能夠通過(guò)多種途徑負向調節機體免疫應答,逃逸機體免疫監管,在腫瘤免疫治療的領(lǐng)域,從早期的細胞因子的發(fā)現,到免疫檢查點(diǎn)抑制劑,單克隆抗體、雙特異性抗體的飛速發(fā)展,包括細胞治療、溶瘤病毒、腫瘤疫苗等方法的出現,免疫療法改變了傳統腫瘤治療的方式,為癌癥患者提供無(wú)限可能。


TAA Mouse Model介紹
腫瘤免疫治療領(lǐng)域的研究依然火熱,針對各靶點(diǎn)科佰生物開(kāi)發(fā)了幾百種報告基因的細胞模型,以及二百多種現貨人源靶點(diǎn)的小鼠細胞模型如下表所示,目前我們已經(jīng)在4T1/CT26/MC-38 等常見(jiàn)的鼠源細胞上進(jìn)行了改造,將人源的熱門(mén)免疫靶點(diǎn)通過(guò)基因手段,穩定表達在細胞上。
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									 4T1  | 
								
									 A20  | 
								
									 ANA-1  | 
								
									 B16-F10  | 
								
									 C1498  | 
								
									 CT26  | 
								
									 EL4  | 
								
									 EMT6  | 
								
									 H22  | 
								
									 Hepa 1-6  | 
								
									 ID8  | 
								
									 KLN205  | 
								
									 LL/2  | 
								
									 MC-38  | 
								
									 MFC  | 
								
									 PANC02  | 
								
									 RENCA  | 
								
									 RM1  | 
							
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									 5T4  | 
								
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									 ADAM9  | 
								
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									 ASCT2  | 
								
									 
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									 B7H3  | 
								
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									 B7H4  | 
								
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									 BCMA  | 
								
									 
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									 CD123  | 
								
									 
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									 CD138  | 
								
									 
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									 CD166  | 
								
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									 CD22  | 
								
									 
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									 CD228  | 
								
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									 CD24  | 
								
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									 CD33  | 
								
									 
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									 CD38  | 
								
									 
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									 CD44  | 
								
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									 CD46  | 
								
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									 CD47  | 
								
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									 CD54  | 
								
									 
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									 CD56  | 
								
									 
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									 CD70  | 
								
									 
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									 CD73  | 
								
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									 mCD73  | 
								
									 
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									 CD74  | 
								
									 
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									 CD79  | 
								
									 
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									 CDCP1  | 
								
									 
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									 CDH17  | 
								
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									 CDH3  | 
								
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									 CDH6  | 
								
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									 CEACAM1  | 
								
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									 CEACAM5  | 
								
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									 CEACAM6  | 
								
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									 Claudin18.2  | 
								
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									 Claudin6  | 
								
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									 Claudin9  | 
								
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									 CLDN1  | 
								
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									 CLDN3  | 
								
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									 CLEC12A  | 
								
									 
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									 DDR1  | 
								
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									 DLK1  | 
								
									 
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									 DLL3  | 
								
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									 DLL4  | 
								
									 
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									 EGFR  | 
								
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									 EGFR&ERBB3  | 
								
									 
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									 ENPP3  | 
								
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									 EpCAM  | 
								
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									 ERBB2  | 
								
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									 ERBB3(HER3)  | 
								
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  | 
								
									 √  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 FAP  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 FGFR  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 FOLR1  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 GPA33  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 GPC1  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 GPC3  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 GPRC5D  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 GUCY2C  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 IL2R  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 KK-LC-1  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 LILRB4  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 LRRC15  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 LY6E  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 LY6G6D  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 MET  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 MSLN  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 MUC1  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 MUC16  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 MUC17  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 Nectin4  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
							
| 
									 NTSR1  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 OVA  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 √  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 √  | 
							
| 
									 PDL1  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 PSMA  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
							
| 
									 PTK7  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 ROR1  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 ROR2  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 SEZ6  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 SLC34A2  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 SLC39A6  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 SORT  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 SSTR2  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
							
| 
									 STEAP1  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
							
| 
									 STEAP1&PSMA  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
							
| 
									 STEAP2  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 TF  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 TFRC  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 TM4SF1  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
							
| 
									 TROP2  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 √  | 
								
									 
  | 
								
									 
  | 
								
									 
  | 
								
									 | 
							
掃二維碼